医学前沿系列讲座（六十九）

（讲座语言：中英文）

题目1：Motor neuron disease: Role of posttranslational modifications of SOD1

内容简介：Motor neuron disease, Pathologically it is characterized by loss of motor neurons in the cortex, brainstem, and spinal cord, leading to progressive muscle weakness, atrophy, and death. Over the past two decades a major breakthrough in ALS research is the discovery that mutations in the gene SOD1 are a cause of familial ALS. Strong evidence supports that the familial ALS-linked SOD1 variants are readily susceptible to posttranslational modifications, and subsequently become misfolded. Therefore, selective knockdown of misfolded SOD1 could be a cure for ALS. Building on a peptide-directed lysosomal protein degradation strategy, we have recently succeeded in selectively knocking down of misfolded SOD1. We are hopeful that this strategy may eventually lead to a cure for ALS.

主讲人：Prof. Jiming Kong（Department of Psychiatry University of Manitoba，Canada）

题目2：Transcriptional Regulation of Brain Derived Neurotrophic Factor (BDNF) by Methyl CPG Binding Protein 2 (MeCP2): Implications in Re-myelination and/or Myelin Repair in an Animal Model of Multiple Sclerosis (MS)

内容简介：The purpose of the lecture is to identify the pathogenic role of the MeCP2E1 isoform in causing myelin damage.

主讲人：Dr. Michael Namaka

（College of Medicine, Faculty of Health Sciences University of Manitoba，Canada）

主持人：黄庆军 教授（汕头大学医学院精神卫生中心）

时 间：2016年4月11日（星期一）下午3:00-5:30

地 点：汕头大学医学院科技楼3楼学术报告厅

欢迎广大师生参加！

主讲人简介见网上通知。

汕头大学医学院科研处

2016年4月5日